Multi-Faceted Validation Of Analysis Conditions For Intrinsic Noise In Transcription-Translation-Degradation Rates
Abstract
Single-physics models fail to describe the multiphysics, multi-time-scale behavior of Intrinsic Noise Transcription. We formulate the phenomenon as a coupled PDE/ODE system, discretize it using a finite-difference discretization with Crank-Nicolson time integration under an accelerated iteration scheme, and identify governing-term candidates via automated equation-form search, benchmarked by rediscovery of a known law. Validation is numerical (grid convergence and parameter sensitivity); external experimental validation is left as future work (measured ±50% sweep: κ +86.1%/-24.4%, γ -44.7%/+551.3%, D -6.4
Contents
- Introduction
- Related Work
- Research Hypotheses
- Method
- Experiments
- Results
- Discussion
- Conclusion
- 9
- figures
- 26
- references
- 6
- tables
